ARTHR-IS Publishes First Paper on S. aureus Prosthetic Joint Infections
COMBACTE-NET's ARTHR-IS study has published its first ever publication in Elsevier's Clinical Microbiology and Infection Journal: "Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: a multinational matched case-control study". Since an increase in prosthetic joint infections (PJI) is expected in the next decade in parallel with the increase in the number of hip and knee arthroplasties performed, identifying the risk factors associated with PJI is a major concern in terms of global health.
Staphylococcus aureus (SA) is a primary cause of prosthetic joint infection (PJI) with serious consequences. This microorganism is frequently associated with treatment failure, hospitalizations and need of prosthesis removal, leading to an important morbidity and an increase in healthcare costs. ARTHR-IS is a retrospective multi-center study which aims to estimate the burden of SA-PJI after a hip or knee arthroplasy and their risk factors through a case-control design. Other objectives are to quantify the costs, number of hospitalizations, surgical procedures to treat and control the infection and finally the factors influencing therapeutic failure.
Reinaldo Espindola (Hospital Universitario de Valme, Seville) is the medical coordinator and academic lead of ARTHR-IS:
Prosthetic joint infections are one of the most complex infections that the clinicians must deal with and those caused by S. aureus one of the most frequent and with the highest failure rates. The identification of the risk factors associated with failure can help to select the best procedure, avoiding unnecessary or excessive consumption of antibiotics and improving the patient’s functionality.
The information obtained within ARTHR-IS will help the design of preventive measures and improve the medical prognosis of this disease. The team collected key information on the incidence and use of healthcare resources to calculate the global burden of prosthetic infection due to S. aureus.
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