LAB-Net Starts Work on NeoOBS Study Clinical Isolates
LAB-Net has received all clinical isolates from 12 sites for the NeoOBS study, a prospective, multicenter, observational cohort study for the management of neonatal sepsis. These isolates are being analysed in the Central Laboratory, LAB-Net, in order to determine their microbial epidemiology, including bacterial identification, antimicrobial susceptibility patterns and resistance mechanisms.
Currently, LAB-Net has received 1006 isolates from 1018 infants from 12 sites. Of these, 815 isolates had identification confirmed by MALDI-TOF. A subset of 415 of isolates have been further analysed and characterised by whole genome sequencing (WGS).
The WGS analysis is focused on Gram-negative pathogens (Klebsiella pneumoniae, Acinetobacter spp., Escherichia coli, and others), but also encompasses methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative Staphylococcus (CoNS) species. The goal of the WGS analysis is to determine the bacterial multilocus sequence typing (MLST) types, clonal diversity, and the characterization of resistomes and virulence genes.
Preliminary results were presented by LAB-Net during the NeoOBS Investigator results meetings scheduled on 13th and 14th of October 2020. Both meetings were web-based due to the COVID-19 pandemic. The LAB-Net team shared some exciting results with all the NeoOBS investigators, and had fruitful discussions on further utilisation of this global dataset.
About NeoOBS Study
The NeoOBS Study (ClinicalTrials.gov Identifier: NCT03721302) is a prospective, multicenter, observational cohort study for the management of neonatal sepsis. It involved 19 hospital sites located in several countries including: Bangladesh (1), Brazil (2), China (3), Greece (1), India (3), Italy (1), Kenya (1), South Africa (3), Thailand (2), Uganda (1), and Vietnam (1). This study has been designed to evaluate current clinical practices and outcomes, and risk factors associated with poor outcomes in infants with sepsis.
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