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Trials
Current status: Report Completed
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ASPIRE-ICU

Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa Infections in EuRopE – Intensive Care Units (ASPIRE-ICU) is a prospective, observational, multicenter, epidemiological cohort study. Nested within routine surveillance among ICU patients in Europe. Aimed at the advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa infections in Europe (ASPIRE).

Predicting risk of infection during ICU stay

The goal is to estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially ventilator-associated pneumonia (VAP). Another goal is to assess its association with patient-related and contextual factors. For example comorbidities, colonization status, and relevant biomarkers. With this information, a risk prediction model will be developed to quantify the risk of acquiring S. aureus or P. aeruginosa pneumonia during ICU stay.

Study information

ASPIRE-ICU was conducted at some twenty sites in ten European countries. After providing consent, a group of 2000 eligible patients was enrolled as subjects. Together they formed a study cohort where active sampling and more elaborate data collection took place. Participants were actively recruited for participation upon ICU admission. And were followed for a certain period of time to determine the frequency of infections. Samples collected were bacterial isolates and serum samples for in-depth microbiological and immunological testing.

Study team members

  • Christine Lammens

    LAB-Net Representative / Laboratory manager / Universiteit Antwerpen

Study level information

General information
  • Study NO NCT02413242
  • Study Name ASPIRE-ICU
  • Study Type Observational
  • Study Status Recruitment Complete
  • Enrollment Period 05/15 - 05/18
Enrollment
  • Total subjects planned 2000
  • Total subjects screened 9561
  • Total subjects enrolled 2006
  • Total subjects completed 1998

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 4
Sites activated 3
Bulgaris
Subjects
planned 280
Subjects
enrolled 127
Subjects
completed 127
Subjects completed
84.7%
Sites planned 2
Sites activated 2
Czech Republic
Subjects
planned 200
Subjects
enrolled 205
Subjects
completed 205
Subjects completed
136.7%
Sites planned 1
Sites activated 1
Estonia
Subjects
planned 70
Subjects
enrolled 152
Subjects
completed 152
Subjects completed
121.6%
Sites planned 4
Sites activated 4
France
Subjects
planned 300
Subjects
enrolled 97
Subjects
completed 97
Subjects completed
64.7%
Sites planned 3
Sites activated 2
Germany
Subjects
planned 210
Subjects
enrolled 49
Subjects
completed 49
Subjects completed
23.3%
Sites planned 3
Sites activated 2
Hungary
Subjects
planned 210
Subjects
enrolled 84
Subjects
completed 84
Subjects completed
56.0%
Sites planned 2
Sites activated 2
Netherlands
Subjects
planned 200
Subjects
enrolled 344
Subjects
completed 344
Subjects completed
114.7%
Sites planned 2
Sites activated 2
Serbia
Subjects
planned 200
Subjects
enrolled 340
Subjects
completed 340
Subjects completed
136.0%
Sites planned 5
Sites activated 5
Spain
Subjects
planned 280
Subjects
enrolled 338
Subjects
completed 338
Subjects completed
96.6%
Sites planned 3
Sites activated 3
Turkey
Subjects
planned 300
Subjects
enrolled 157
Subjects
completed 157
Subjects completed
78.5%
Sites planned 3
Sites activated 3
Great Britain
Subjects
planned 300
Subjects
enrolled 106
Subjects
completed 106
Subjects completed
70.7%

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