COMBACTE-NET (Combatting bacterial resistance in Europe – networks) is dedicated to building strong clinical, laboratory and research networks across Europe. In doing so, the consortium enables more efficient clinical testing of novel antimicrobial drugs. In addition, it performs several of those clinical trials as well.
COMBACTE-NET aims to
- provide a large network for rapid evaluation of novel treatment strategies;
- generate innovative trial designs to facilitate the registration of novel antibacterial agents;
- design and validate tests to support the diagnosis of patients, identify the most appropriate treatments, and monitor the patient’s response.
One of the key outcomes of COMBACTE-NET is a high-quality European clinical trial and laboratory network in which new antibacterial drugs can be evaluated for the treatment and prevention of infections caused by multi-resistant bacteria. Over 650 laboratories and over 850 clinical trial sites all over Europe are already interconnected. These networks will enable the collection of data required for accurately identifying clinical needs and coming up with ideas for developing effective new antibacterial treatment options. An important aspect of the networks is that they will form the backbone for all clinical studies within the wider ND4BB program.
- CLIN-Net is a network of clinics and hospitals offering access to fast numbers of patients and with the capability to perform high-quality clinical trials.
- LAB-Net is a network of microbiology laboratories delivering high-quality and standardized information on microbial strains and antibiotic resistance.
- STAT-Net is a network of academic and industry experts on clinical trial design working to optimize the design of Phase II and Phase III clinical trials.
The COMBACTE-NET consortium will top off the construction of this clinical trial backbone by carrying out several clinical trials of candidate drugs.
- Suvratoxumab (formerly MEDI4893) is a monoclonal antibody from MedImmune, the global biologics research and development arm of AstraZeneca, that could protect mechanically ventilated patients against infections with Staphylococcus aureus, preventing bacterial toxins from damaging their organs and tissues;
- Da Volterra’s DAV132 is a promising new therapeutic agent for the prevention of serious Clostridium difficile infections. In the ANTICIPATE study, it is tested for safety and pharmacokinetics. In essence, it adsorbs small molecules such as antibiotics, preventing bacteria present in the gut from harming the patient;
- The Medicines Company offers an intravenous formulation of minocycline, effective against infections due to Acinetobacter species. COMBACTE-NET performs the regulatory tests required to make it available in Europe.
Management Board Members COMBACTE-NET
From left to right: Prof. Dr. Marc Bonten (UMC Utrecht), Dr. Helen Steel (GSK), Dr. Bruno François (CHU Limoges), Dr. Hasan Jafri (MedImmune), Dr. Annie Ducher (DaVolterra), Dr. Michael Dudley (The Medicines Company)
Project Management Office COMBACTE-NET
From left to right: Elodie Pfender (CHU Limoges), Terramika Bellamy (MedImmune), Claire-Marie Martis (UMC Utrecht), Giselle Gift (MedImmune), Ron de Winter (UMC Utrecht), Drieke Vandamme (CHU Limoges), Michelle Linfesty (The Medicines Company)