Study Update RESCUING
The past decades have been characterized by remarkable progress in health-care systems that have contributed to greater longevity of the population. An unfortunate consequence of this is increased levels of comorbidity amongst hospital patients. Simultaneously, an overwhelming increase in bacterial resistance, especially among Gram-negative bacilli, has been observed.
Complicated urinary tract infections (cUTI), including those related to urinary catheterization, urological surgery, ureteral obstruction, stent infections or ascending pyelonephritis, are frequent causes of hospital admission or could develops during hospitalization for other indications. A combination of factors, including age, comorbidities and high antibiotic multi-resistance have considerably hampered the treatment of cUTI and increased the need to find new antibiotics or combinations that can address the current problems of bacterial resistance.
The RESCUING study is a multinational, multicenter, retrospective observational study to assess the clinical management, outcomes and costs of hospitalized patients with cUTI in intensive care units and hospital wards and to identify the risk factors associated with treatment failure in this cohort of patients. The data was gathered from 20 hospitals located in 8 South and Eastern European countries and Israel with high prevalence of multidrug resistant Gram-negative bacteria. The data was collected retrospectively and about 30-80 cases of cUTI were included per center from patients hospitalized between January 2013 and December 2014.
A total of 1,009 evaluable cases have been collected with the final case entered on 17th July 2016. All queries were solved and the database was locked on 12th August 2016. The data has been exported and data analysis was started in August 2016. A statistical analysis group consisting of Academic and EFPIA members of this workpackage will meet periodically to discuss the data analysis results. Potential publications related to this workpackage are already being considered.
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