Molecules against Gram-negative infections in intensive-care units

COMBACTE-MAGNET (Combatting bacterial resistance in Europe – Molecules against Gram-negative infections) focuses on the most vulnerable category of patients: those who are critically ill and being treated in intensive-care units. Gram-negative bacteria cause most ICU-associated infections. This project aims to find better options to deal with that threat.


  • linking available surveillance systems in Europe;
  • provide phase I, II, and III studies;
  • analyze data about current microbial threats, treatment and drug resistance patterns;
  • gather information on biological markers of Pseudomonas aeruginosa infections;
  • create mathematical models of the infection’s effects;
  • provide a better understanding of the different response of patients to infections;
  • provide knowledge to design more efficient and effective clinical trials of new molecules