Current status: Report Completed


Arthroplasties’ infections due to Staphylococcus aureus (ARTHR-IS): Due to the aging population, the number of arthroplasties is expected to grow in the next few years. Staphylococcus aureus (SA) is a primary cause of prosthesis joint infection (PJI) with serious consequences. This microorganism is frequently associated with treatment failure, hospitalizations and need of prosthesis removal, leading to an important morbidity and an increase in healthcare costs.

Estimating the Burden of SA-PJI

ARTHR-IS is a retrospective multi-center study which aims to estimate the burden of SA-PJI after a hip or knee arthroplasy and their risk factors through a case-control design. Other objectives are to quantify the costs, number of hospitalizations, surgical procedures to treat and control the infection and finally the factors influencing therapeutic failure.

Study information

ARTHR-IS selected 20 hospitals across 5 European countries in order to include 150 cases and 450 controls. This project is a collaborative initiative between the Hospital Virgen Macarena in Sevilla and GlaxoSmithKline as academic and EFPIA partners respectively. The results of this study will provide critical information to develop strategies to prevent and treat SA-PJI and reduce treatment failures. Also the results from ARTHR-IS study will help in the design of future clinical trials to prevent SA-PJI prosthesis infection by providing reliable estimates on the incidence of SA-PJI and the subsequent burden on health care services.


Important Pieces Of A Puzzle


Reflections On COMBACTE-NET