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ASPIRE-ICU
Current status: Active Recruiting
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Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa Infections in EuRopE ā€“ Intensive Care Units

ASPIRE-ICU is a prospective, observational, multicenter, epidemiologic cohort study. Nested within routine surveillance among ICU patients in Europe. Aimed at the advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa infections in Europe (ASPIRE).

Predicting risk of infection during ICU stay

The goal is to estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially ventilator-associated pneumonia (VAP). Another goal is to assess its association with patient-related and contextual factors. For example comorbidities, colonization status, and relevant biomarkers. With this information, a risk prediction model will be developed to quantify the risk of acquiring S. aureus or P. aeruginosa pneumonia during ICU stay.

Study information

ASPIRE-ICU will be conducted at some twenty sites in ten European countries. After providing consent, a group of 2000 eligible patients will be enrolled as subjects. Together they form a study cohort where active sampling and more elaborate data collection will take place. Participants will be actively recruited for participation upon ICU admission. And will be followed for a certain period of time to determine the frequency of infections. Samples that will be collected are bacterial isolates and serum samples for in-depth microbiological and immunological testing.

Study team members

  • Chantal Hendriks

    Data manager / Academic / UMC Utrecht

  • Christine Lammens

    Laboratory Manager / Academic / University of Antwerp

Study level information

General information
  • Study NO NCT02413242
  • Study Name ASPIRE-ICU
  • Study Type Observational
  • Study Status Active Recruiting
  • Enrollment Period 05/15 - 05/18
Enrollment
  • Total subjects planned 2000
  • Total subjects screened 6107
  • Total subjects enrolled 1639
  • Total subjects completed 1403

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 4
Sites activated 3
Bulgaris
Subjects
planned
280
Subjects
enrolled
89
Subjects
completed
75
Subjects completed
50.0%
Sites planned 2
Sites activated 1
Czech Republic
Subjects
planned
200
Subjects
enrolled
136
Subjects
completed
83
Subjects completed
55.3%
Sites planned 1
Sites activated 1
Estonia
Subjects
planned
70
Subjects
enrolled
104
Subjects
completed
93
Subjects completed
74.4%
Sites planned 4
Sites activated 3
France
Subjects
planned
300
Subjects
enrolled
74
Subjects
completed
57
Subjects completed
38.0%
Sites planned 3
Sites activated 2
Germany
Subjects
planned
0
Subjects
enrolled
49
Subjects
completed
45
Subjects completed
0.0%
Sites planned 3
Sites activated 3
Hungary
Subjects
planned
210
Subjects
enrolled
84
Subjects
completed
75
Subjects completed
50.0%
Sites planned 2
Sites activated 2
Netherlands
Subjects
planned
200
Subjects
enrolled
304
Subjects
completed
267
Subjects completed
89.0%
Sites planned 2
Sites activated 2
Serbia
Subjects
planned
200
Subjects
enrolled
261
Subjects
completed
228
Subjects completed
91.2%
Sites planned 5
Sites activated 4
Spain
Subjects
planned
280
Subjects
enrolled
303
Subjects
completed
273
Subjects completed
78.0%
Sites planned 3
Sites activated 3
Turkey
Subjects
planned
300
Subjects
enrolled
159
Subjects
completed
137
Subjects completed
68.5%
Sites planned 3
Sites activated 3
Great Britain
Subjects
planned
300
Subjects
enrolled
91
Subjects
completed
70
Subjects completed
46.7%