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ASPIRE-ICU
Current status: Recruitment Completed
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Advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa Infections in EuRopE ā€“ Intensive Care Units

ASPIRE-ICU is a prospective, observational, multicenter, epidemiologic cohort study. Nested within routine surveillance among ICU patients in Europe. Aimed at the advanced understanding of Staphylococcus aureus and Pseudomonas aeruginosa infections in Europe (ASPIRE).

Predicting risk of infection during ICU stay

The goal is to estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially ventilator-associated pneumonia (VAP). Another goal is to assess its association with patient-related and contextual factors. For example comorbidities, colonization status, and relevant biomarkers. With this information, a risk prediction model will be developed to quantify the risk of acquiring S. aureus or P. aeruginosa pneumonia during ICU stay.

Study information

ASPIRE-ICU will be conducted at some twenty sites in ten European countries. After providing consent, a group of 2000 eligible patients will be enrolled as subjects. Together they form a study cohort where active sampling and more elaborate data collection will take place. Participants will be actively recruited for participation upon ICU admission. And will be followed for a certain period of time to determine the frequency of infections. Samples that will be collected are bacterial isolates and serum samples for in-depth microbiological and immunological testing.

Study team members

Study level information

General information
  • Study NO NCT02413242
  • Study Name ASPIRE-ICU
  • Study Type Observational
  • Study Status Recruitment Complete
  • Enrollment Period 05/15 - 05/18
Enrollment
  • Total subjects planned 2000
  • Total subjects screened 9561
  • Total subjects enrolled 2006
  • Total subjects completed 1838

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 4
Sites activated 3
Bulgaris
Subjects
planned
280
Subjects
enrolled
127
Subjects
completed
108
Subjects completed
72.0%
Sites planned 2
Sites activated 2
Czech Republic
Subjects
planned
200
Subjects
enrolled
208
Subjects
completed
170
Subjects completed
113.3%
Sites planned 1
Sites activated 1
Estonia
Subjects
planned
70
Subjects
enrolled
152
Subjects
completed
125
Subjects completed
100.0%
Sites planned 4
Sites activated 4
France
Subjects
planned
300
Subjects
enrolled
99
Subjects
completed
86
Subjects completed
57.3%
Sites planned 3
Sites activated 2
Germany
Subjects
planned
210
Subjects
enrolled
49
Subjects
completed
49
Subjects completed
23.3%
Sites planned 3
Sites activated 3
Hungary
Subjects
planned
210
Subjects
enrolled
84
Subjects
completed
84
Subjects completed
56.0%
Sites planned 2
Sites activated 2
Netherlands
Subjects
planned
200
Subjects
enrolled
344
Subjects
completed
330
Subjects completed
110.0%
Sites planned 2
Sites activated 2
Serbia
Subjects
planned
200
Subjects
enrolled
337
Subjects
completed
297
Subjects completed
118.8%
Sites planned 5
Sites activated 5
Spain
Subjects
planned
280
Subjects
enrolled
339
Subjects
completed
324
Subjects completed
92.6%
Sites planned 3
Sites activated 3
Turkey
Subjects
planned
300
Subjects
enrolled
161
Subjects
completed
160
Subjects completed
80.0%
Sites planned 3
Sites activated 3
Great Britain
Subjects
planned
300
Subjects
enrolled
106
Subjects
completed
105
Subjects completed
70.0%