Advanced understanding of StaPhylococcus aureus Infections in EuRopE – Surgical SiteInfections
ASPIRE-SSI is a prospective, observational, multicenter cohort study performed with adult surgical patients as subjects. The study aims to engender advanced understanding of Staphylococcus aureus infections in Europe (ASPIRE) incurred in surgical site infections (SSIs).
Predicting risk of infection during surgery
The primary objective of ASPIRE-SSI is to determine the incidence of S. aureus SSIs in various adult surgical patient populations. Another aim is to identify the patient-related, pathogen-related, and contextual risk factors. Immunologic features protective against S. aureus SSI will also be assessed.
The knowledge obtained from this study will enable identification of the patients most at risk of developing S. aureus SSI. It should also indicate who would probably benefit the most from new prophylactic interventions.
ASPIRE-SSI is a prospective, observational, multicenter cohort study that will be conducted at 35 sites in 10 countries across Europe. In total, approximately 15000 patients will be consented, and about 1/3 will be enrolled in the study cohort. They will provide demographic and clinical data, as well as serological and microbiological specimens for testing. Eligible for enrolment in the study are adult surgical patients who will be undergoing planned or unplanned surgery from a preselected set of surgical procedures, and who are preoperatively screened for S. aureus colonization.
Study team members
Scientist / EFPIA / MedImmune
Clinical Trial Administrator / Academic / UMC Utrecht
EFPIA / MedImmune
Study level information
- Study NO NCT02935244
- Study Name ASPIRE-SSI
- Study Type Observational
- Study Status Active Recruiting
- Enrollment Period 12/16 - 01/19
- Total subjects planned 5000
- Total subjects screened 10393
- Total subjects enrolled 3972
- Total subjects completed 3044
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- Preparation phase
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- Trial period
Country level information