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ASPIRE-SSI
Current status: Active Recruiting
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Advanced understanding of StaPhylococcus aureus Infections in EuRopESurgical SiteInfections

ASPIRE-SSI is a prospective, observational, multicenter cohort study performed with adult surgical patients as subjects. The study aims to engender advanced understanding of Staphylococcus aureus infections in Europe (ASPIRE) incurred in surgical site infections (SSIs).

Predicting risk of infection during surgery

The primary objective of ASPIRE-SSI is to determine the incidence of S. aureus SSIs in various adult surgical patient populations. Another aim is to identify the patient-related, pathogen-related, and contextual risk factors. Immunologic features protective against S. aureus SSI will also be assessed.

The knowledge obtained from this study will enable identification of the patients most at risk of developing S. aureus SSI. It should also indicate who would probably benefit the most from new prophylactic interventions.

Study information

ASPIRE-SSI is a prospective, observational, multicenter cohort study that will be conducted at 35 sites in 10 countries across Europe. In total, approximately 15000 patients will be consented, and about 1/3 will be enrolled in the study cohort. They will provide demographic and clinical data, as well as serological and microbiological specimens for testing. Eligible for enrolment in the study are adult surgical patients who will be undergoing planned or unplanned surgery from a preselected set of surgical procedures, and who are preoperatively screened for S. aureus colonization.

Study team members

Study level information

General information
  • Study NO NCT02935244
  • Study Name ASPIRE-SSI
  • Study Type Observational
  • Study Status Active Recruiting
  • Enrollment Period 12/16 - 01/19
Enrollment
  • Total subjects planned 5000
  • Total subjects screened 10393
  • Total subjects enrolled 3972
  • Total subjects completed 3044

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 2
Sites activated 2
Belgium
Subjects
planned
0
Subjects
enrolled
29
Subjects
completed
7
Subjects completed
0.0%
Sites planned 4
Sites activated 0
Czech Republic
Subjects
planned
500
Subjects
enrolled
175
Subjects
completed
34
Subjects completed
6.8%
Sites planned 2
Sites activated 2
Estonia
Subjects
planned
250
Subjects
enrolled
153
Subjects
completed
136
Subjects completed
54.4%
Sites planned 1
Sites activated 1
France
Subjects
planned
150
Subjects
enrolled
286
Subjects
completed
247
Subjects completed
164.7%
Sites planned 3
Sites activated 3
Italy
Subjects
planned
400
Subjects
enrolled
359
Subjects
completed
272
Subjects completed
68.0%
Sites planned 3
Sites activated 3
Netherlands
Subjects
planned
875
Subjects
enrolled
756
Subjects
completed
550
Subjects completed
62.9%
Sites planned 5
Sites activated 4
Romania
Subjects
planned
850
Subjects
enrolled
109
Subjects
completed
62
Subjects completed
7.3%
Sites planned 3
Sites activated 3
Serbia
Subjects
planned
550
Subjects
enrolled
954
Subjects
completed
833
Subjects completed
151.5%
Sites planned 5
Sites activated 5
Spain
Subjects
planned
1050
Subjects
enrolled
676
Subjects
completed
590
Subjects completed
56.2%
Sites planned 7
Sites activated 6
Great Britain
Subjects
planned
1000
Subjects
enrolled
475
Subjects
completed
312
Subjects completed
31.2%