ASPIRE-SSI
Current status: Active Recruiting
combacte-net

Advanced understanding of StaPhylococcus aureus Infections in EuRopESurgical SiteInfections

ASPIRE-SSI is a prospective, observational, multicenter cohort study performed with adult surgical patients as subjects. The study aims to engender advanced understanding of Staphylococcus aureus infections in Europe (ASPIRE) incurred in surgical site infections (SSIs).

Predicting risk of infection during surgery

The primary objective of ASPIRE-SSI is to determine the incidence of S. aureus SSIs in various adult surgical patient populations. Another aim is to identify the patient-related, pathogen-related, and contextual risk factors. Immunologic features protective against S. aureus SSI will also be assessed.

The knowledge obtained from this study will enable identification of the patients most at risk of developing S. aureus SSI. It should also indicate who would probably benefit the most from new prophylactic interventions.

Study information

ASPIRE-SSI is a prospective, observational, multicenter cohort study that will be conducted at 35 sites in 10 countries across Europe. In total, approximately 15000 patients will be consented, and about 1/3 will be enrolled in the study cohort. They will provide demographic and clinical data, as well as serological and microbiological specimens for testing. Eligible for enrolment in the study are adult surgical patients who will be undergoing planned or unplanned surgery from a preselected set of surgical procedures, and who are preoperatively screened for S. aureus colonization.

Study team members

Study level information

General information
  • Study NO NCT02935244
  • Study Name ASPIRE-SSI
  • Study Type Observational
  • Study Status Active Recruiting
  • Enrollment Period 12/16 - 01/19
Enrollment
  • Total subjects planned 5000
  • Total subjects screened 12569
  • Total subjects enrolled 4946
  • Total subjects completed 4461

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 2
Sites activated 2
Belgium
Subjects
planned
0
Subjects
enrolled
58
Subjects
completed
33
Subjects completed
0.0%
Sites planned 4
Sites activated 4
Czech Republic
Subjects
planned
500
Subjects
enrolled
351
Subjects
completed
288
Subjects completed
57.6%
Sites planned 2
Sites activated 2
Estonia
Subjects
planned
250
Subjects
enrolled
174
Subjects
completed
163
Subjects completed
65.2%
Sites planned 1
Sites activated 1
France
Subjects
planned
150
Subjects
enrolled
348
Subjects
completed
319
Subjects completed
212.7%
Sites planned 3
Sites activated 3
Italy
Subjects
planned
400
Subjects
enrolled
420
Subjects
completed
361
Subjects completed
90.3%
Sites planned 3
Sites activated 3
Netherlands
Subjects
planned
875
Subjects
enrolled
812
Subjects
completed
778
Subjects completed
88.9%
Sites planned 5
Sites activated 4
Romania
Subjects
planned
850
Subjects
enrolled
131
Subjects
completed
128
Subjects completed
15.1%
Sites planned 3
Sites activated 3
Serbia
Subjects
planned
550
Subjects
enrolled
1157
Subjects
completed
1076
Subjects completed
195.6%
Sites planned 5
Sites activated 5
Spain
Subjects
planned
1050
Subjects
enrolled
778
Subjects
completed
725
Subjects completed
69.0%
Sites planned 7
Sites activated 6
Great Britain
Subjects
planned
1000
Subjects
enrolled
717
Subjects
completed
591
Subjects completed
59.1%