The Base of COMBACTE's Future

Read more
Current status: Recruitment Completed
combacte-net

ASPIRE-SSI

Advanced understanding of StaPhylococcus aureus Infections in EuRopE - Surgical Site Infections (ASPIRE-SSI) is a prospective, observational, multicenter cohort study performed with adult surgical patients as subjects. The study aims to engender advanced understanding of Staphylococcus aureus infections in Europe (ASPIRE) incurred in surgical site infections (SSIs).

Predicting risk of infection during surgery

The primary objective of ASPIRE-SSI is to determine the incidence of S. aureus SSIs in various adult surgical patient populations. Another aim is to identify the patient-related, pathogen-related, and contextual risk factors. Immunologic features protective against S. aureus SSI will also be assessed. The knowledge obtained from this study will enable identification of the patients most at risk of developing S. aureus SSI. It should also indicate who would probably benefit the most from new prophylactic interventions.

Study information

ASPIRE-SSI is a prospective, observational, multicenter cohort study that was conducted at 35 sites in 10 countries across Europe. In total, approximately 15,000 patients consented, and about 1/3 were enrolled in the study cohort. They provided demographic and clinical data, as well as serological and microbiological specimens for testing. Eligible for enrolment in the study were adult surgical patients who would be undergoing planned or unplanned surgery from a preselected set of surgical procedures, and who were preoperatively screened for S. aureus colonization.

Study team members

  • Beatrijs Wolters

    Program Coordinator / Academic / University Medical Center Utrecht

  • Christine Lammens

    LAB-Net Representative / Academic / University of Antwerp

Study level information

General information
  • Study NO NCT02935244
  • Study Name ASPIRE-SSI
  • Study Type Observational
  • Study Status Recruitment Complete
  • Enrollment Period 12/16 - 01/19
Enrollment
  • Total subjects planned 5000
  • Total subjects screened 12680
  • Total subjects enrolled 5003
  • Total subjects completed 4991

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 2
Sites activated 2
Belgium
Subjects
planned
0
Subjects
enrolled
57
Subjects
completed
57
Subjects completed
0.0%
Sites planned 4
Sites activated 4
Czech Republic
Subjects
planned
500
Subjects
enrolled
373
Subjects
completed
369
Subjects completed
73.8%
Sites planned 2
Sites activated 2
Estonia
Subjects
planned
250
Subjects
enrolled
177
Subjects
completed
174
Subjects completed
69.6%
Sites planned 1
Sites activated 1
France
Subjects
planned
150
Subjects
enrolled
348
Subjects
completed
335
Subjects completed
223.3%
Sites planned 3
Sites activated 3
Italy
Subjects
planned
400
Subjects
enrolled
424
Subjects
completed
392
Subjects completed
98.0%
Sites planned 3
Sites activated 3
Netherlands
Subjects
planned
875
Subjects
enrolled
814
Subjects
completed
795
Subjects completed
90.9%
Sites planned 5
Sites activated 4
Romania
Subjects
planned
850
Subjects
enrolled
126
Subjects
completed
123
Subjects completed
14.5%
Sites planned 3
Sites activated 3
Serbia
Subjects
planned
550
Subjects
enrolled
1166
Subjects
completed
1101
Subjects completed
200.2%
Sites planned 5
Sites activated 5
Spain
Subjects
planned
1050
Subjects
enrolled
780
Subjects
completed
761
Subjects completed
72.5%
Sites planned 7
Sites activated 6
Great Britain
Subjects
planned
1000
Subjects
enrolled
738
Subjects
completed
699
Subjects completed
69.9%
27/11/2020

Getting Familiar with CDI

23/11/2020

Pillars of COMBACTE: LAB-Net