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ASPIRE-SSI
Current status: Active Recruiting
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Advanced understanding of StaPhylococcus aureus Infections in EuRopESurgical SiteInfections

ASPIRE-SSI is a prospective, observational, multicenter cohort study performed with adult surgical patients as subjects. The study aims to engender advanced understanding of Staphylococcus aureus infections in Europe (ASPIRE) incurred in surgical site infections (SSIs).

Predicting risk of infection during surgery

The primary objective of ASPIRE-SSI is to determine the incidence of S. aureus SSIs in various adult surgical patient populations. Another aim is to identify the patient-related, pathogen-related, and contextual risk factors. Immunologic features protective against S. aureus SSI will also be assessed.

The knowledge obtained from this study will enable identification of the patients most at risk of developing S. aureus SSI. It should also indicate who would probably benefit the most from new prophylactic interventions.

Study information

ASPIRE-SSI is a prospective, observational, multicenter cohort study that will be conducted at 35 sites in 10 countries across Europe. In total, approximately 15000 patients will be consented, and about 1/3 will be enrolled in the study cohort. They will provide demographic and clinical data, as well as serological and microbiological specimens for testing. Eligible for enrolment in the study are adult surgical patients who will be undergoing planned or unplanned surgery from a preselected set of surgical procedures, and who are preoperatively screened for S. aureus colonization.

Study team members

Study level information

General information
  • Study NO NCT02935244
  • Study Name ASPIRE-SSI
  • Study Type Observational
  • Study Status Active Recruiting
  • Enrollment Period 12/16 - 01/19
Enrollment
  • Total subjects planned 5000
  • Total subjects screened 11157
  • Total subjects enrolled 4307
  • Total subjects completed 3625

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 2
Sites activated 2
Belgium
Subjects
planned
0
Subjects
enrolled
34
Subjects
completed
19
Subjects completed
0.0%
Sites planned 4
Sites activated 4
Czech Republic
Subjects
planned
500
Subjects
enrolled
257
Subjects
completed
124
Subjects completed
24.8%
Sites planned 2
Sites activated 2
Estonia
Subjects
planned
250
Subjects
enrolled
156
Subjects
completed
147
Subjects completed
58.8%
Sites planned 1
Sites activated 1
France
Subjects
planned
150
Subjects
enrolled
298
Subjects
completed
279
Subjects completed
186.0%
Sites planned 3
Sites activated 3
Italy
Subjects
planned
400
Subjects
enrolled
375
Subjects
completed
303
Subjects completed
75.8%
Sites planned 3
Sites activated 3
Netherlands
Subjects
planned
875
Subjects
enrolled
772
Subjects
completed
640
Subjects completed
73.1%
Sites planned 5
Sites activated 4
Romania
Subjects
planned
850
Subjects
enrolled
130
Subjects
completed
112
Subjects completed
13.2%
Sites planned 3
Sites activated 3
Serbia
Subjects
planned
550
Subjects
enrolled
1035
Subjects
completed
921
Subjects completed
167.5%
Sites planned 5
Sites activated 5
Spain
Subjects
planned
1050
Subjects
enrolled
707
Subjects
completed
651
Subjects completed
62.0%
Sites planned 7
Sites activated 6
Great Britain
Subjects
planned
1000
Subjects
enrolled
543
Subjects
completed
427
Subjects completed
42.7%