Current status: Ongoing
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HONEST-PREPS

HOspital NEtwork STudy – Preparation for a Randomized Evaluation of anti-Pneumonia Strategies (HONEST-PREPS) is a prospective, observational, multicenter cohort study. The study population are the patients admitted to an intensive care unit (ICU) at risk for hospital acquired and ventilator associated pneumonia (HAP/VAP).

The aim of the HONEST-PREPS is to set up an infrastructure to prospectively enroll patients at risks of HAP/VAP in the ICU. Collected data will be used to inform future diagnostic, preventative and therapeutic trials. In addition to capturing HAP/VAP episodes in a timely manner, HONEST-PREPS will determine the incidence, microbiological etiology (including antibiotic resistance), management and outcome of HAP/VAP in the ICU.

Study status: Preparation phase (2019 May – March 2020), Trial period (March 2020 – ongoing)

Country level information:

  • Serbia: 3 sites recruiting, 1 site in start-up process
  • Czech Republic: 2 sites recruiting, 2 sites initiated and pending activation
  • Croatia: 1 site recruiting and 2 sites in start-up process
  • Romania: 1 site recruiting
  • Hungary: 1 site in start-up process
  • Latvia: 2 sites in start-up process
  • Albania: 1 site in start-up process
  • France: 1 site recruiting

Planned study duration

HONEST-PREPS observational study is a preparation for a subsequent platform trial (HONEST-PLATFORM: HOspital NEtwork STudy – PLAtform Trial FOR antibacterial Molecules). The set-up of the infrastructure, training of clinical staff and laboratory staff, data collection and preparation for the HONEST-PLATFORM is expected to take 18-24 months.

Study team members

  • Christine Lammens

    LAB-Net Representative / Laboratory manager / University of Antwerp

  • Henri van Werkhoven

    Investigator / Coordinating investigator / University Medical Center Utrecht

  • Herman Goossens

    Collaborator / Academic / University of Antwerp

Study level information

General information
  • Study NO N/A
  • Study Name HONEST-PREPS
  • Study Type Observational
  • Study Status Active Recruiting
  • Enrollment Period N/A - N/A
Enrollment
  • Total subjects planned 6200
  • Total subjects screened 1458
  • Total subjects enrolled 916
  • Total subjects completed 0

Study timeline

Light blue
Preparation phase
Dark blue
Trial period

Country level information

Filter
Sites planned 0
Sites activated 1
Albania
Subjects
planned
200
Subjects
enrolled
31
Subjects
completed
0
Subjects completed
0.0%
Sites planned 0
Sites activated 1
Croatia
Subjects
planned
1000
Subjects
enrolled
48
Subjects
completed
0
Subjects completed
0.0%
Sites planned 0
Sites activated 1
Czech Republic
Subjects
planned
1600
Subjects
enrolled
444
Subjects
completed
0
Subjects completed
0.0%
Sites planned 0
Sites activated 1
France
Subjects
planned
200
Subjects
enrolled
0
Subjects
completed
0
Subjects completed
0.0%
Sites planned 0
Sites activated 0
Latvia
Subjects
planned
800
Subjects
enrolled
0
Subjects
completed
0
Subjects completed
0.0%
Sites planned 0
Sites activated 1
Romania
Subjects
planned
800
Subjects
enrolled
86
Subjects
completed
0
Subjects completed
0.0%
Sites planned 0
Sites activated 3
Serbia
Subjects
planned
1600
Subjects
enrolled
307
Subjects
completed
0
Subjects completed
0.0%
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LAB-Net prepared sites for VALUE-Dx trials